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KMID : 0359720140320020091
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Journal of the Korean Neurological Association
2014 Volume.32 No. 2 p.91 ~ p.94
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Steroid Responsive Recurrent Limbic Encephalitis Associated With LGI1 Antibodies
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Noh Kyung-Ha
Kim Seung-Joo
Cho Jae-Wook
Shin Jin-Hong
Lee Jae-Hyeok
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Abstract
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Limbic encephalitis (LE) is characterized by short-term memory loss, disorientation, agitation, seizures, and histological evidence of mesial temporal lobe inflammation. Leucine-rich, glioma inactivated 1 (LGI1) is the autoantigen associated with limbic encephalitis that was previously attributed to voltage-gated potassium channels. We report herein a 54-year-old female with LGI1-related limbic encephalitis who presented with recurrent episodes of episodic memory impairment, depressive mood, and phantosmia. Her symptoms dramatically improved with steroid therapy.
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KEYWORD
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LGI1 encephalitis, Limbic encephalitis
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